HCV
Phylogeography of the General Population and High-Risk
Groups in Cyprus Identifies the Island as a Global Sink
for and Source of Infection
Hepatitis C virus (HCV) genotype and subtype distribution
differs according to geographic origin and transmission
risk category. Previous molecular epidemiology studies
suggest the presence of multiple subtypes among Cypriot
subjects. To investigate HCV genotype- and subtype-specific
dissemination patterns, origins, and transmission in Cyprus,
we analyzed HCV sequences encoding partial Core-E1 and
NS5B regions.
Source
Population
density and water balance influence the global occurrence
of hepatitis E epidemics
In developing countries, the waterborne transmission of
hepatitis E virus (HEV), caused by HEV genotypes 1 (HEV-1)
and 2 (HEV-2), leads to the onset of large recurrent outbreaks.
HEV infections are of particular concern among pregnant
women, due to very high mortality rates (up to 70%). Unfortunately,
good understanding of the factors that trigger the occurrence
of HEV epidemics is currently lacking; therefore, anticipating
the onset of an outbreak is yet not possible.
Source
Infection
with multiple hepatitis C virus genotypes detected using
commercial tests should be confirmed using next generation
sequencing
Current HCV genotyping methods may have some limitations
in detecting mixed infections. We aimed to determine the
accuracy of genotyping and the detection of mixed-genotype
infections using the Abbott-RealTime HCV Genotype II assay
(Abbott-RT-PCR) in comparison with a Roche-Next Generation
Sequencing assay (Roche-NGS).
Source
Liver
sinusoidal endothelial cells (LSECs) modifications in
patients with chronic hepatitis C
The sinusoidal endothelial cells present in the liver
(LSECs) are tipically characterized by the presence of
pores (fenestrae). During some pathological conditions
LSECs undergo “capillarization”, a process
characterized by loss of fenestrations and acquisition
of a vascular phenotype. In chronic liver disease capillarization
has been reported to precede the development of fibrosis.
Source
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